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Modulating Mitophagy in Mitochondrial Disease

16 Jun 2017

Abstract excerpt

Mitochondrial diseases may result from mutations in the maternally-inherited mitochondrial DNA (mtDNA) or from mutations in nuclear genes encoding mitochondrial proteins. Their bi-genomic nature makes mitochondrial diseases a very heterogeneous group of disorders that can present at any age and can affect any type of tissue. The autophagic-lysosomal degradation pathway plays an important role in clearing...

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PMID: 28618992
DOI: 10.2174/0929867324666170616101741

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