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Article

Targeting autophagy and mitophagy for mitochondrial diseases treatment

2 Nov 2015

Abstract excerpt

INTRODUCTION: Mitochondrial diseases are a group of rare genetic diseases with complex and heterogeneous origins which manifest a great variety of phenotypes. Disruption of the oxidative phosphorylation system is the main cause of pathogenicity in mitochondrial diseases since it causes accumulation of reactive oxygen species (ROS) and ATP depletion. AREAS COVERED: Current evidences support the main protective...

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PMID: 26523761
DOI: 10.1517/14728222.2016.1101068

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