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Article

Costimulatory protein 4IgB7H3 drives the malignant phenotype of glioblastoma by mediating immune escape and invasiveness.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2012

Lemke Dieter, Pfenning Philipp-Niclas, Sahm Felix, Klein Ann-Catherine, Kempf Tore, Warnken Uwe, Schnölzer Martina, Tudoran Ruxandra, Weller Michael, Platten Michael, Wick Wolfgang

Abstract excerpt

PURPOSE: Recent work points out a role of B7H3, a member of the B7-family of costimulatory proteins, in conveying immunosuppression and enforced invasiveness in a variety of tumor entities. Glioblastoma is armed with effective immunosuppressive properties resulting in an impaired recognition and ineffective attack of tumor cells by the immune system. In addition, extensive and diffuse invasion of tumor cells into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22080438
DOI: 10.1158/1078-0432.CCR-11-0880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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