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Article

Evaluation of the free α-hemoglobin pool in red blood cells: a new test providing a scale of β-thalassemia severity.

American journal of hematology - 1 Feb 2011

Vasseur Corinne, Pissard Serge, Domingues-Hamdi Elisa, Marden Michael C, Galactéros Frédéric, Baudin-Creuza Véronique

Abstract excerpt

β-Thalassemias are characterized by an imbalance of globin chains with an excess of α-chains which precipitates in erythroid precursors and red blood cells (RBCs) leading to inefficient erythropoiesis. The severity of the disease correlates with the amount of unpaired α-chains.Our goal was to develop a simple test for evaluation of the free α-hemoglobin pool present in RBC lysates. Alpha-Hemoglobin Stabilizing...

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Source

Identifiers

PMID: 21264907
DOI: 10.1002/ajh.21918

Genes

AHSP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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