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Article

NOTCH1 mutations influence survival in chronic lymphocytic leukemia patients.

BMC cancer - 4 Jun 2013

Willander Kerstin, Dutta Ravi Kumar, Ungerbäck Jonas, Gunnarsson Rebeqa, Juliusson Gunnar, Fredrikson Mats, Linderholm Mats, Söderkvist Peter

Abstract excerpt

BACKGROUND: NOTCH1 PEST domain mutations in chronic lymphocytic leukemia have recently been shown to be of prognostic relevance. Both NOTCH1 and NOTCH2 are constitutively activated in B-cell CLL but not expressed in normal B cells and may be involved in survival and resistance to apoptosis in CLL. We screened for mutations in different parts of both NOTCH1 and NOTCH2 genes and related the changes to survival and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Polymorphism, Single-Stranded Conformational

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Share to Receptor, Notch1

Source

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Identifiers

PMID: 23734977
DOI: 10.1186/1471-2407-13-274
PMCID: PMC3679784

Genes

NOTCH1
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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