Article

DNA Double-Strand Break Response and Repair Gene Polymorphisms May Influence Therapy Results and Prognosis in Head and Neck Cancer Patients

2023-09-28

Abstract excerpt

Radiotherapy and cisplatin-based chemotherapy belong to the main treatment modalities for head and neck squamous cell carcinoma (HNSCC), and induce cancer cell death by generating DNA damage, including the most severe double strand breaks (DSBs). Alterations in DSB response and repair genes may affect individual DNA repair capacity and treatment sensitivity, contributing to therapy resistance and poor prognosis of...

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Literature Corpus work: d20a1dfa-6a98-5a3c-8b1a-cdc6b2b577b9
DOI: 10.20944/preprints202309.1941.v1

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