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Minireview: Autophagy in Pancreatic β-Cells and Its Implication in Diabetes

29 Jan 2015

Abstract excerpt

Autophagy is a conserved system for the degradation of cytoplasmic proteins and organelles. During insulin resistance, in which insulin secretion is enhanced and β-cell mass is increased owing to changes in the expression and function of various proteins in pancreatic β-cells, autophagic activity appears to also be enhanced to adapt to the dynamic changes occurring in β-cells. Indeed, defective autophagy in...

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PMID: 25633274
DOI: 10.1210/me.2014-1367

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