Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance.

doi:10.1016/j.metabol.2011.09.018

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Article

Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance.

Metabolism: clinical and experimental - 1 May 2012

Underwood Patricia C, Chamarthi Bindu, Williams Jonathan S, Sun Bei, Vaidya Anand, Raby Benjamin A, Lasky-Su Jessica, Hopkins Paul N, Adler Gail K, Williams Gordon H

Abstract excerpt

Insulin resistance (IR) is a complex disorder caused by an interplay of both genetic and environmental factors. Recent studies identified a significant interaction between body mass index (BMI) and the rs1800795 polymorphism of the interleukin-6 gene that influences both IR and onset of type 2 diabetes mellitus, with obese individuals homozygous for the C allele demonstrating the highest level of IR and greatest...

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PMID: 22075267
DOI: 10.1016/j.metabol.2011.09.018
PMCID: PMC3461261

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