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Article

Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infection.

Retrovirology - 10 Nov 2011

Iglesias Candela, Ringeard Mathieu, Di Nunzio Francesca, Fernandez Juliette, Gaudin Raphael, Souque Philippe, Charneau Pierre, Arhel Nathalie

Abstract excerpt

UNLABELLED: BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) central DNA Flap is generated during reverse transcription as a result of (+) strand initiation at the central polypurine tract (cPPT) and termination after a ca. 100 bp strand displacement at the central termination sequence (CTS). The central DNA Flap is a determinant of HIV-1 nuclear import, however, neither cPPT nor CTS mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22074589
DOI: 10.1186/1742-4690-8-92
PMCID: PMC3227589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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