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Article

Nuclear import defect of human immunodeficiency virus type 1 DNA flap mutants is not dependent on the viral strain or target cell type.

Journal of virology - 1 Oct 2006

Arhel Nathalie, Munier Sandie, Souque Philippe, Mollier Karine, Charneau Pierre

Abstract excerpt

We have previously established, using human immunodeficiency virus type 1 (HIV-1) strain LAI, that the HIV-1 central DNA Flap acts as a cis determinant of viral genome nuclear import. Although the impact of the DNA Flap on nuclear import has already found numerous independent confirmations in the context of lentivirus vectors, it has been claimed that it may be nonessential for infectious virus strains LAI, YU-2...

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Identifiers

PMID: 17005705
DOI: 10.1128/JVI.00974-06
PMCID: PMC1617309

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