Article
A possible overestimation of the effect of acetylation on lysine residues in KQ mutant analysis.
Journal of computational chemistry - 30 Jan 2012
Fujimoto Hirofumi, Higuchi Mariko, Koike Manabu, Ode Hirotaka, Pinak Miroslav, Bunta Juraj Kotulic, Nemoto Toshiyuki, Sakudoh Takashi, Honda Naoko, Maekawa Hideaki, Saito Kimiaki, Tsuchida Kozo
Abstract excerpt
Acetylation of lysine residues, one of the most common protein post-transcriptional modifications, is thought to regulate protein affinity with other proteins or nucleotides. Experimentally, the effects of acetylation have been studied using recombinant mutants in which lysine residues (K) are substituted with glutamine (Q) as a mimic of acetyl lysine (KQ mutant), or with arginine (R) as a mimic of nonacetylated...
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