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Article

Structure of a Sir2 substrate, Alba, reveals a mechanism for deacetylation-induced enhancement of DNA binding.

The Journal of biological chemistry - 11 Jul 2003

Zhao Kehao, Chai Xiaomei, Marmorstein Ronen

Abstract excerpt

The targeted acetylation status of histones and several other transcriptional regulatory proteins plays an important role in gene expression, although the mechanism for this is not well understood. As a model to understand how targeted acetylation may effect transcription, we determined the x-ray crystal structure of the chromatin protein Alba from Archaeoglobus fulgidus, a substrate for the Sir2 protein that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12730210
DOI: 10.1074/jbc.M303666200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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