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Article

Computational study of the W260A activating mutant of Src tyrosine kinase.

Protein science : a publication of the Protein Society - 1 Jan 2016

Meng Yilin, Roux Benoît

Abstract excerpt

Tyrosine kinases are enzymes playing a critical role in cellular signaling. Mutations causing increased in kinase activity are often associated with cancer and various pathologies. One example in Src tyrosine kinases is offered by the substitution of the highly conserved tryptophan 260 by an alanine (W260A), which has been shown to cause an increase in activity. Here, molecular dynamics simulations based on...

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Identifiers

PMID: 26106037
DOI: 10.1002/pro.2731
PMCID: PMC4815304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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