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Article

High frequency of BTG1 deletions in acute lymphoblastic leukemia in children with down syndrome.

Genes, chromosomes & cancer - 1 Feb 2012

Lundin Catarina, Hjorth Lars, Behrendtz Mikael, Nordgren Ann, Palmqvist Lars, Andersen Mette Klarskov, Biloglav Andrea, Forestier Erik, Paulsson Kajsa, Johansson Bertil

Abstract excerpt

Previous cytogenetic studies of myeloid and acute lymphoblastic leukemias in children with Down syndrome (ML-DS and DS-ALL) have revealed significant differences in abnormality patterns between such cases and acute leukemias in general. Also, certain molecular genetic aberrations characterize DS-related leukemias, such as GATA1 mutations in ML-DS and deregulation of the CRLF2 gene in DS-ALL. Whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22072402
DOI: 10.1002/gcc.20944

Genes

BTG1
SERP2
BTLA
CRLF2
ETV6
GATA1
IKZF1
PAX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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