Article
Gene alterations involving the CRLF2-JAK pathway and recurrent gene deletions in Down syndrome-associated acute lymphoblastic leukemia in Japan.
Genes, chromosomes & cancer - 1 Nov 2014
Hanada Isamu, Terui Kiminori, Ikeda Fumika, Toki Tsutomu, Kanezaki Rika, Sato Tomohiko, Kamio Takuya, Kudo Ko, Sasaki Shinya, Takahashi Yoshihiro, Hayashi Yasuhide, Inukai Takeshi, Kojima Seiji, Koike Kenichi, Kosaka Yoshiyuki, Kobayashi Masao, Imaizumi Masue, Mitsui Tetsuo, Hori Hiroki, Hara Junichi, Horibe Keizo, Nagai Jun-ichi, Goto Hiroaki, Ito Etsuro
Abstract excerpt
In Western countries, gene alterations involving the CRLF2-JAK signaling pathway are identified in approximately 50-60% of patients with Down syndrome-associated acute lymphoblastic leukemia (DS-ALL), and this pathway is considered a potential therapeutic target. The frequency of BTG1 deletions in DS-ALL is controversial. IKZF1 deletions, found in 20-30% of DS-ALL patients, are associated with a poor outcome and...
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