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Article

Screening strategies for a highly polymorphic gene: DHPLC analysis of the Fanconi anemia group A gene.

Journal of biochemical and biophysical methods - 30 Jan 2001

Rischewski J, Schneppenheim R

Abstract excerpt

INTRODUCTION: Patients with Fanconi anemia (Fanc) are at risk of developing leukemia. Mutations of the group A gene (FancA) are most common. A multitude of polymorphisms and mutations within the 43 exons of the gene are described. To examine the role of heterozygosity as a risk factor for malignancies, a partially automatized screening method to identify aberrations was needed. We report on our experience with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11179761
DOI: 10.1016/s0165-022x(00)00151-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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