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Article

Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid.

Kidney international - 1 Mar 2012

Jelaković Bojan, Karanović Sandra, Vuković-Lela Ivana, Miller Frederick, Edwards Karen L, Nikolić Jovan, Tomić Karla, Slade Neda, Brdar Branko, Turesky Robert J, Stipančić Želimir, Dittrich Damir, Grollman Arthur P, Dickman Kathleen G

Abstract excerpt

Endemic (Balkan) nephropathy is a chronic tubulointerstitial disease frequently accompanied by urothelial cell carcinomas of the upper urinary tract. This disorder has recently been linked to exposure to aristolochic acid, a powerful nephrotoxin and human carcinogen. Following metabolic activation, aristolochic acid reacts with genomic DNA to form aristolactam-DNA adducts that generate a unique TP53 mutational...

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Identifiers

PMID: 22071594
DOI: 10.1038/ki.2011.371
PMCID: PMC3560912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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