Article
Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania.
Environmental and molecular mutagenesis - 1 Oct 2012
Schmeiser Heinz H, Kucab Jill E, Arlt Volker M, Phillips David H, Hollstein Monica, Gluhovschi Gheorghe, Gluhovschi Cristina, Modilca Mirela, Daminescu Liviu, Petrica Ligia, Velciov Silvia
Abstract excerpt
Recently, chronic Aristolochia poisoning was found responsible for the aetiology of Balkan endemic nephropathy (BEN) in Croatia, Serbia, and Bosnia, and diet was the likely route of exposure to aristolochic acid (AA). BEN, often associated with an increased incidence of upper urinary tract carcinoma (UUC), also affects residents of certain rural villages in Romania. AA is a nephrotoxin and human carcinogen that...
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