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Naturally Occurring Structural Isomers in Serum IgA1 <i>O</i> -Glycosylation

8 Nov 2011

Abstract excerpt

IgA is the most abundantly produced antibody and plays an important role in the mucosal immune system. Human IgA is represented by two isotypes, IgA1 and IgA2. The major structural difference between these two subclasses is the presence of nine potential sites of O-glycosylation in the hinge region between the first and second constant region domains of the heavy chain. Thr(225), Thr(228), Ser(230), Ser(232) and...

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PMID: 22067045
DOI: 10.1021/pr200608q

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