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Article

Role of donor genital tract HIV-1 diversity in the transmission bottleneck

7 Nov 2011

Abstract excerpt

The predominant mode of HIV-1 infection is heterosexual transmission, where a genetic bottleneck is imposed on the virus quasispecies. To probe whether limited genetic diversity in the genital tract (GT) of the transmitting partner drives this bottleneck, viral envelope sequences from the blood and genital fluids of eight transmission pairs from Rwanda and Zambia were analyzed. The chronically infected...

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PMID: 22065783
DOI: 10.1073/pnas.1103764108

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