Article
HIV type 1 genetic variation in foreskin and blood from subjects in Rakai, Uganda.
AIDS research and human retroviruses - 1 Jul 2012
Galiwango Ronald M, Lamers Susanna L, Redd Andrew D, Manucci Jordyn, Tobian Aaron A R, Sewankambo Nelson, Kigozi Godfrey, Nakigozi Gertrude, Serwadda David, Boaz Iga, Nalugoda Fred, Sullivan David J, Kong Xiangrong, Wawer Maria J, Gray Ronald H, Quinn Thomas C, Laeyendecker Oliver
Abstract excerpt
The foreskin contains a subset of dendritic cells, macrophages, and CD4(+) and CD8(+) T cells that may be targets for initial HIV infection in female-to-male sexual transmission of HIV-1. We present analyses comparing HIV-1 sequences isolated from foreskin DNA and serum RNA in 12 heterosexual men enrolled in an adult male circumcision trial performed in Rakai, Uganda. Phylogenetic analysis demonstrated three...
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