Article
The major risk alleles of age-related macular degeneration (AMD) in CFH do not play a major role in rheumatoid arthritis (RA).
Clinical and experimental immunology - 1 Dec 2011
Trouw L A, Böhringer S, Daha N A, Stahl E A, Raychaudhuri S, Kurreeman F A, Stoeken-Rijsbergen G, Houwing-Duistermaat J J, Huizinga T W, Toes R E
Abstract excerpt
Because activation of the alternative pathway (AP) of the complement system is an important aspect of both age-related macular degeneration (AMD) and rheumatoid arthritis (RA), we wished to address the question whether genetic risk factors of the AP inhibitor complement factor H (CFH) for AMD would also be risk factors for RA. For this purpose we genotyped single nucleotide polymorphisms (SNPs) in a Dutch set of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.