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Article

R102G polymorphism of the C3 gene associated with exudative age-related macular degeneration in a French population.

Molecular vision - 15 Jul 2010

Zerbib Jennyfer, Richard Florence, Puche Nathalie, Leveziel Nicolas, Cohen Salomon Y, Korobelnik Jean-François, Sahel José, Munnich Arnold, Kaplan Josseline, Rozet Jean-Michel, Souied Eric H

Abstract excerpt

PURPOSE: Major genetic factors for age-related macular degeneration (AMD) have recently been identified as susceptibility risk factors, underlying the role of the complement pathway in AMD. Our purpose was to analyze the role of the R102G polymorphism of the complement component (C3) gene in a French population, in a case-control study. METHODS: A total of 1,080 patients with exudative AMD and 406 controls were...

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Identifiers

PMID: 20664795
PMCID: PMC2905636

Genes

ARMS2
CFH

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