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Article

Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse.

Experimental physiology - 1 Jan 2012

Matsakas Antonios, Macharia Raymond, Otto Anthony, Elashry Mohamed I, Mouisel Etienne, Romanello Vanina, Sartori Roberta, Amthor Helge, Sandri Marco, Narkar Vihang, Patel Ketan

Abstract excerpt

Myostatin regulates both muscle mass and muscle metabolism. The myostatin null (MSTN(-/-)) mouse has a hypermuscular phenotype owing to both hypertrophy and hyperplasia of the myofibres. The enlarged muscles display a reliance on glycolysis for energy production; however, enlarged muscles that develop in the absence of myostatin have compromised force-generating capacity. Recent evidence has suggested that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22058168
DOI: 10.1113/expphysiol.2011.063008

Genes

MSTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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