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Article

Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash.

Physiological genomics - 16 Jun 2005

Cho Hye-Youn, Jedlicka Anne E, Clarke Robert, Kleeberger Steven R

Abstract excerpt

The mechanisms of susceptibility to particle-induced lung injury are not clearly understood. To evaluate the contribution of genetic background to pulmonary pathogenesis, we compared the lung injury responses to residual oil fly ash (ROFA) in inbred mouse strains and calculated heritability estimates. Significant interstrain (genetic) variation was observed in ROFA-induced lung inflammation and hyperpermeability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15784698
DOI: 10.1152/physiolgenomics.00037.2005

Genes

TLR4
MYD88
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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