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Article

Apolipoprotein E genotype affects innate susceptibility to Listeria monocytogenes infection in aged male mice.

Infection and immunity - 14 Sept 2023

Cho Jooyoung, Alexander Katie L, Ferrell Jessica L, Johnson Lance A, Estus Steven, D'Orazio Sarah E F

Abstract excerpt

Apolipoprotein E (ApoE) is a lipid transport protein that is hypothesized to suppress proinflammatory cytokine production, particularly after stimulation with Toll-like receptor (TLR) ligands such as lipopolysaccharide (LPS). Studies using transgenic ApoE human replacement mice (APOE) expressing one of three different allelic variants suggest that there is a hierarchy in terms of responsiveness to proinflammatory...

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Identifiers

PMID: 37594272
DOI: 10.1128/iai.00251-23
PMCID: PMC10501219

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