Article
Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.
Cancer research - 1 Apr 2005
Hagiwara Tomoko, Kono Suminori, Yin Guang, Toyomura Kengo, Nagano Jun, Mizoue Tetsuya, Mibu Ryuichi, Tanaka Masao, Kakeji Yoshihiro, Maehara Yoshihiko, Okamura Takeshi, Ikejiri Kouji, Futami Kitaroh, Yasunami Youichi, Maekawa Takafumi, Takenaka Kenji, Ichimiya Hitoshi, Imaizumi Nobutoshi
Abstract excerpt
Bile acids have long been implicated in the etiology of colorectal cancer, but epidemiologic evidence remains elusive. Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme in the synthesis of bile acids from cholesterol in the liver, and thus may be an important determinant of bile acid production. We examined the association between the CYP7A1 A-203C polymorphism and colorectal cancer. The CYP7A1...
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