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Article

Contributions of histone H3 nucleosome core surface mutations to chromatin structures, silencing and DNA repair.

PloS one - 1 Jan 2011

Fink Michel, Thompson Jeffrey S, Thoma Fritz

Abstract excerpt

Histone H3 mutations in residues that cluster in a discrete region on the nucleosome surface around lysine 79 of H3 affect H3-K79 methylation, impair transcriptional silencing in subtelomeric chromatin, and reveal distinct contributions of histone H3 to various DNA-damage response and repair pathways. These residues might act by recruitment of silencing and DNA-damage response factors. Alternatively, their...

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Identifiers

PMID: 22053185
DOI: 10.1371/journal.pone.0026210
PMCID: PMC3203891

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Source receipt: pubmed, retrieved 7 Sept 2026.

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