Article
Differential contributions of histone H3 and H4 residues to heterochromatin structure.
Genetics - 1 Jun 2011
Yu Qun, Olsen Lars, Zhang Xinmin, Boeke Jef D, Bi Xin
Abstract excerpt
Transcriptional silencing in Saccharomyces cerevisiae is mediated by heterochromatin. There is a plethora of information regarding the roles of histone residues in transcriptional silencing, but exactly how histone residues contribute to heterochromatin structure is not resolved. We address this question by testing the effects of a series of histone H3 and H4 mutations involving residues in their aminoterminal...
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