Article
Non-classical HLA-E gene variability in Brazilians: a nearly invariable locus surrounded by the most variable genes in the human genome.
Tissue antigens - 1 Jan 2012
Veiga-Castelli L C, Castelli E C, Mendes C T, da Silva W A, Faucher M-C, Beauchemin K, Roger M, Moreau P, Donadi E A
Abstract excerpt
The non-classical human leukocyte antigen (HLA) class I genes present a very low rate of variation. So far, only 10 HLA-E alleles encoding three proteins have been described, but only two are frequently found in worldwide populations. Because of its historical background, Brazilians are very suitable for population genetic studies. Therefore, 104 bone marrow donors from Brazil were evaluated for HLA-E exons 1-4....
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