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Article

Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype.

Scientific reports - 31 May 2021

Sakabe Tomohiko, Wakahara Makoto, Shiota Goshi, Umekita Yoshihisa

Abstract excerpt

Mammary serine protease inhibitor (maspin) is a tumor suppressor gene that is downregulated during carcinogenesis and breast cancer progression. While the nuclear localization of maspin is essential for tumor suppression, we previously reported that the cytoplasmic localization of maspin was significantly correlated with poor prognosis in breast cancer patients. To understand the mechanisms that underlie...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34059749
DOI: 10.1038/s41598-021-90887-z
PMCID: PMC8166868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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