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Article

An evolutionary framework for common diseases: the ancestral-susceptibility model.

Trends in genetics : TIG - 1 Nov 2005

Di Rienzo Anna, Hudson Richard R

Abstract excerpt

Unlike rare mendelian diseases, which are due to new mutations (i.e. derived alleles), several alleles that increase the risk to common diseases are ancestral. Moreover, population genetics studies suggest that some derived alleles that protect against common diseases became advantageous recently. These observations can be explained within an evolutionary framework in which ancestral alleles reflect ancient...

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Identifiers

PMID: 16153740
DOI: 10.1016/j.tig.2005.08.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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