Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.

doi:10.3899/jrheum.110235

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Article

Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.

The Journal of rheumatology - 1 Jan 2012

Broen Jasper C A, Dieude Phillipe, Vonk Madelon C, Beretta Lorenzo, Carmona Francisco D, Herrick Ariane, Worthington Jane, Hunzelmann Nicholas, Riemekasten Gabriela, Kiener Hans, Scorza Rafaella, Simeon Carmen P, Fonollosa Vicent, Carreira Patricia, Ortego-Centeno Norberto, Gonzalez-Gay Miguel A, Airo' Paolo, Coenen Marieke J, Tsang Kelly, Aliprantis Antonios O, Martin Javier, Allanore Yannick, Radstake Timothy R D J

Abstract excerpt

OBJECTIVE: Polymorphisms in the genes encoding interleukin 4 (IL4), interleukin 13 (IL13), and their corresponding receptors have been associated with multiple immune-mediated diseases. Our aim was to validate these previous observations in patients with systemic sclerosis (SSc) and scrutinize the effect of the polymorphisms on gene expression in various populations of peripheral blood leukocytes. METHODS: We...

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PMID: 22045834
DOI: 10.3899/jrheum.110235

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