Article
The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype.
Annals of the rheumatic diseases - 1 Feb 2009
Rueda B, Broen J, Torres O, Simeon C, Ortego-Centeno N, Schrijvenaars M M V A P, Vonk M C, Fonollosa V, van den Hoogen F H J, Coenen M J H, Sanchez-Román J, Aguirre-Zamorano M A, García-Portales R, Pros A, Camps M T, Gonzalez-Gay M A, Martin J, Radstake T R D J
Abstract excerpt
OBJECTIVES: Multiple studies indicate the role of the interleukin (IL)-17/IL-23 axis in autoimmune diseases, including systemic sclerosis (SSc). The aim of the current study was to investigate the possible implication of the IL23R gene in SSc susceptibility and/or clinical phenotype. METHODS: An initial case-control study in 143 Dutch patients with SSc and geographically matched healthy individuals (n = 246) was...
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