Article
Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.
Arthritis research & therapy - 1 Jan 2008
Marinou Ioanna, Till Simon H, Moore David J, Wilson Anthony G
Abstract excerpt
INTRODUCTION: A feature of rheumatoid arthritis (RA) is an imbalance between proinflammatory and anti-inflammatory cytokines. Several recent studies have implicated polymorphism in the IL-4 signalling pathway in the development of erosive RA. The aim of the present study was to investigate the role of polymorphism in the IL-4, IL-4Ralpha and IL-13 genes in RA, including an examination of epistasis. METHODS: A...
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