Article
Evaluation of interleukin 13 polymorphisms in systemic sclerosis.
Immunogenetics - 1 Aug 2006
Granel Brigitte, Chevillard Christophe, Allanore Yannick, Arnaud Violaine, Cabantous Sandrine, Marquet Sandrine, Weiller Pierre-Jean, Durand Jean-Marc, Harlé Jean-Robert, Grange Claire, Frances Yves, Berbis Philippe, Gaudart Jean, de Micco Philippe, Kahan André, Dessein Alain
Abstract excerpt
Systemic sclerosis (SSc) is a multisystem disease of unknown etiology. It is characterized by excessive cutaneous and visceral fibrosis, damage to small blood vessels, and production of autoantibodies. Interleukin-13 (IL-13) has been shown to be involved in abnormal fibrosis in other diseases. Therefore, we have evaluated its possible involvement in SSc. We analyzed four IL13 gene polymorphisms, rs1800925...
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