Article
The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility.
The Journal of rheumatology - 1 Mar 2011
Broen Jasper C A, Coenen Marieke J H, Rueda Blanca, Witte Torsten, Padyukov Leonid, Klareskog Lars, Hesselstrand Roger, Wuttge Dirk M, Simeon Carmen, Ortego-Centeno Norberto, González-Gay Miguel A, Pros Anna, Hunzelman Nicholas, Riemekasten Gabriela, Kreuter Alexander, Vonk Madelon, Scorza Rafaella, Beretta Lorenzo, Airò Paulo, van Riel Piet L C M, Kimberly Robert, Martin Javier, Edberg Jeffrey, Radstake Timothy R D J
Abstract excerpt
OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We...
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