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Article

Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.

Journal of neuroscience research - 1 Feb 2004

Hashimoto Yuichi, Tsukamoto Emi, Niikura Takako, Yamagishi Yohichi, Ishizaka Miho, Aiso Sadakazu, Takashima Akihiko, Nishimoto Ikuo

Abstract excerpt

Presenilin (PS)1 and its mutants, which consist of the N-terminal and C-terminal fragments, cause certain familial forms of Alzheimer's disease (FAD). Our earlier studies found that FAD-linked M146L-PS1 causes neuronal cell death through nitrogen oxide synthase (NOS) and that FAD-linked N141I-PS2...

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Identifiers

PMID: 14743455
DOI: 10.1002/jnr.10861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14743455-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.PMID 14743455Read ↗

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