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Article

Measuring selection coefficients below 10(-3): method, questions, and prospects.

Genetics - 1 Jan 2012

Gallet Romain, Cooper Tim F, Elena Santiago F, Lenormand Thomas

Abstract excerpt

Measuring fitness with precision is a key issue in evolutionary biology, particularly in studying mutations of small effects. It is usually thought that sampling error and drift prevent precise measurement of very small fitness effects. We circumvented these limits by using a new combined approach to measuring and analyzing fitness. We estimated the mutational fitness effect (MFE) of three independent mini-Tn10...

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Share to Epistasis, Genetic
Share to Escherichia coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22042578
DOI: 10.1534/genetics.111.133454
PMCID: PMC3249376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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