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Article

A framework for evolutionary systems biology.

BMC systems biology - 24 Feb 2009

Loewe Laurence

Abstract excerpt

BACKGROUND: Many difficult problems in evolutionary genomics are related to mutations that have weak effects on fitness, as the consequences of mutations with large effects are often simple to predict. Current systems biology has accumulated much data on mutations with large effects and can predict the properties of knockout mutants in some systems. However experimental methods are too insensitive to observe...

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Identifiers

PMID: 19239699
DOI: 10.1186/1752-0509-3-27
PMCID: PMC2663779

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