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Article

Variation in the fitness effects of mutations with population density and size in Escherichia coli.

PloS one - 1 Jan 2014

Cao Huansheng, Butler Kevin, Hossain Mithi, Lewis James D

Abstract excerpt

The fitness effects of mutations are context specific and depend on both external (e.g., environment) and internal (e.g., cellular stress, genetic background) factors. The influence of population size and density on fitness effects are unknown, despite the central role population size plays in the supply and fixation of mutations. We addressed this issue by comparing the fitness of 92 Keio strains (Escherichia...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25121498
DOI: 10.1371/journal.pone.0105369
PMCID: PMC4133409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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