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Article

Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis.

The Journal of biological chemistry - 2 Feb 2007

Jennemann Richard, Sandhoff Roger, Langbein Lutz, Kaden Sylvia, Rothermel Ulrike, Gallala Hichem, Sandhoff Konrad, Wiegandt Herbert, Gröne Hermann-Josef

Abstract excerpt

Ceramides are vital components of the water barrier in mammalian skin. Epidermis-specific, a major ceramide portion contains omega-hydroxy very long chain fatty acids (C30-C36). These omega-hydroxy ceramides (Cers) are found in the extracellular lamellae of the stratum corneum either as linoleic acyl esters or protein bound. Glucosylceramide is the major glycosphingolipid of the epidermis. Synthesized from...

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PMID: 17145749
DOI: 10.1074/jbc.M610304200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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