Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular determinants of beta-carboline inhibition of the glycine receptor.

Journal of neurochemistry - 1 Sept 2009

Chen Xuebin, Cromer Brett A, Lynch Joseph W

Abstract excerpt

beta-Carbolines are potent modulators of GABA type A receptors and they have recently been shown to inhibit glycine receptors in a subunit-specific manner. The present study screened four structurally similar beta-carbolines, 1,2,3,4-tetrahydronorharmane, norharmane, harmane and 6-methoxyharmalan...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Cell Line
Share to Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Structure, Secondary

Share to Protein Subunits

Share to Receptors, Glycine

Share to Recombinant Proteins

Source

Identifiers

PMID: 19619142
DOI: 10.1111/j.1471-4159.2009.06273.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19619142-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular determinants of beta-carboline inhibition of the glycine receptor.PMID 19619142Read ↗

Molecular determinants of ginkgolide binding in the glycine receptor pore.Semantic proximity Read ↗

Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site.Semantic proximity Read ↗

Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels.Semantic proximity Read ↗

Subunit-specific potentiation of recombinant glycine receptors by NV-31, a bilobalide-derived compound.Semantic proximity Read ↗

Different binding modes of tropeines mediating inhibition and potentiation of alpha1 glycine receptors.Semantic proximity Read ↗

Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition.Semantic proximity Read ↗

Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation.Semantic proximity Read ↗

Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist.Semantic proximity Read ↗

Gating mechanism of the human α1β GlyR by glycineSemantic proximity Read ↗

Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.Semantic proximity Read ↗

Structure and function of inhibitory glycine receptors.Semantic proximity Read ↗

Structural insight into the mechanism of 4-aminoquinolines selectivity for the alpha2A-adrenoceptorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.