Article
Enhancing effects of salicylate on quinidine-induced block of human wild type and LQT3 related mutant cardiac Na+ channels.
Biomedical research (Tokyo, Japan) - 1 Oct 2011
Urashima Tadashi, Kurata Yasutaka, Miake Junichiro, Kato Masaru, Ogura Kazuyoshi, Yano Akio, Adachi Masamitsu, Tanaka Yasunori, Yamada Kensaku, Hamada Toshihiro, Mizuta Einosuke, Kuwabara Masanari, Kato Masahiko, Yamamoto Yasutaka, Ogino Kazuhide, Yoshida Akio, Shirayoshi Yasuaki, Hisatome Ichiro
Abstract excerpt
It is unknown whether salicylate enhances the action of antiarrhythmic agents on human Na+ channels with state dependency and tissue specificity. We therefore investigated effects of salicylate on quinidine-induced block of human cardiac and skeletal muscle Na+ channels. Human cardiac wild-type (hH1), LQT3-related mutant (ΔKPQ), and skeletal muscle (hSkM1) Na+ channel α subunits were expressed in COS7 cells....
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