Article
Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness.
Breast cancer research : BCR - 27 Oct 2011
Lips Esther H, Laddach Nadja, Savola Suvi P, Vollebergh Marieke A, Oonk Anne M M, Imholz Alex L T, Wessels Lodewyk F A, Wesseling Jelle, Nederlof Petra M, Rodenhuis Sjoerd
Abstract excerpt
INTRODUCTION: Our group has previously employed array Comparative Genomic Hybridization (aCGH) to assess the genomic patterns of BRCA1-mutated breast cancers. We have shown that the so-called BRCA1-like(aCGH) profile is also present in about half of all triple-negative sporadic breast cancers and is predictive for benefit from intensified alkylating chemotherapy. As aCGH is a rather complex method, we translated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.