Article
Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study.
BMC cancer - 19 Oct 2016
Gross Eva, van Tinteren Harm, Li Zhou, Raab Sandra, Meul Christina, Avril Stefanie, Laddach Nadja, Aubele Michaela, Propping Corinna, Gkazepis Apostolos, Schmitt Manfred, Meindl Alfons, Nederlof Petra M, Kiechle Marion, Lips Esther H
Abstract excerpt
BACKGROUND: Triple-negative breast cancer (TNBC) with a BRCA1-like molecular signature has been demonstrated to remarkably respond to platinum-based chemotherapy and might be suited for a future treatment with poly(ADP-ribose)polymerase (PARP) inhibitors. In order to rapidly assess this signature we have previously developed a multiplex-ligation-dependent probe amplification (MLPA)-based assay. Here we present an...
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