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Article

BRCAness digitalMLPA profiling predicts benefit of intensified platinum-based chemotherapy in triple-negative and luminal-type breast cancer.

Breast cancer research : BCR - 25 Jul 2020

Lips Esther H, Benard-Slagter Anne, Opdam Mark, Scheerman Caroline E, Wesseling Jelle, Hogervorst Frans B L, Linn Sabine C, Savola Suvi, Nederlof Petra M

Abstract excerpt

BACKGROUND: We previously showed that BRCA-like profiles can be used to preselect individuals with the highest risk of carrying BRCA mutations but could also indicate which patients would benefit from double-strand break inducing chemotherapy. A simple, robust, and reliable assay for clinical use that utilizes limited amounts of formalin-fixed, paraffin-embedded tumor tissue to assess BRCAness status in both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32711554
DOI: 10.1186/s13058-020-01313-7
PMCID: PMC7382055

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