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Article

High expression of HLA-E in colorectal carcinoma is associated with a favorable prognosis.

Journal of translational medicine - 27 Oct 2011

Benevolo Maria, Mottolese Marcella, Tremante Elisa, Rollo Francesca, Diodoro Maria Grazia, Ercolani Cristiana, Sperduti Isabella, Lo Monaco Elisa, Cosimelli Maurizio, Giacomini Patrizio

Abstract excerpt

BACKGROUND: Human Leukocyte Antigen (HLA)-E is a non-classical class I HLA molecule that can be stabilized by ligands donated by other classical (HLA-A, -B, -C) and non-classical (HLA-G) family members. HLA-E engages a variety of immune receptors expressed by cytotoxic T lymphocytes (CTLs), Natural killer (NK) cells and NK-CTLs. In view of the opposing outcomes (activation or inhibition) of the different HLA-E...

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Identifiers

PMID: 22032294
DOI: 10.1186/1479-5876-9-184
PMCID: PMC3219584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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