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HLA-E gene polymorphism and expression in colorectal cancer patients.

Human immunology - 1 Feb 2026

Dhouioui Sabrine, Boujelbene Nadia, Hasni Marwa, Mansouri Houyem, Bourogâa Hager, Jalouli Maroua, Mokrani Amina, Mchiri Rym, Harrath Abdel Halim, Zemni Ines, Rebmann Vera, Zidi Ines

Abstract excerpt

HLA-E has been proposed as an immunomodulatory molecule in various physiological and pathological contexts. However, few data are available on its involvement in bowel oncogenesis. Our aim was to investigate whether HLA-E gene polymorphism and its expression as soluble molecules (sHLA-E) contribute to colorectal cancer (CRC) pathology in the Tunisian population. A total of 240 CRC patients and 254...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41481968
DOI: 10.1016/j.humimm.2025.111652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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