Article
Sclerostin: how human mutations have helped reveal a new target for the treatment of osteoporosis.
Drug discovery today - 1 Jul 2013
Robinson Martyn K, Caminis John, Brunkow Mary E
Abstract excerpt
In the 1990s there was a tremendous mood of optimism among pharmaceutical scientists that identification of disease-associated variations in the human genome would result in a surge of new drug targets (the 'gene-to-drug' mantra). To date the expected deluge of new drugs has not arrived. However, a small number of drugs arising directly from the study of rare human disorders showing Mendelian inheritance are now...
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